AM3: AM3 technology is an ingredient with immunoregulatory activity made from the non-covalent association of a phosphorylated α-glucomannan polysaccharide and a soy protein, stabilised with an inorganic matrix of phosphate and calcium sulphates and used as a dietary supplement sold as Inmunoferon®. It has excellent bioavailability thanks to its resistance of enzymatic degradation and stomach pH, as well as the fact that it is not altered by the liver's metabolism and does not alter the hepatic conjugation system. ACTIVITIES:

• Immune response modulator (1, 2).
• Inflammation regulator (3–8).
• Adjuvant in vaccination (1, 6, 9)
• Possible role against immunosenescence and oxidative stress (10, 11).

POLYAMINES (SPERMIDINE): Polyamines, such as putrescine, spermidine, are bioactive polycations capable of modulating many signalling pathways. Thus, these polyamines, which are very ubiquitous given how they are found in all living cells, are involved in a whole series of biological processes, fundamentally related to cell viability, proliferation and differentiation. This makes them essential for the development and survival of mammals and must be maintained in optimal quantities to show their positive effects. Although certain studies show both positive and negative effects (mainly at large doses) on human health, its benefits on cardiac and brain activity and increasing life expectancy seem to be proven for the most part. In fact, the concentrations of these polyamines are decreased in many pathological conditions as well as with aging, and their administration in adequate quantities has been recommended to reduce the risk of diseases, such as cardiovascular, neurological or cancer. Polyamines demonstrate antioxidant and anti-inflammatory properties, controlling the redox and inflammation status of cells, the reason why their relevance for our health has become evident and would explain their role in increasing longevity (12–20). Given the involvement of polyamines in processes such as autophagy, some of them such as spermidine can control neurodegeneration and include in the group of those called “rapalogues” due to presenting an action similar to rapamycin, and consequently suggested to increase the longevity (11, 21, 22). The role of sperm in DNA methylation processes also explains how diets rich in polyamines can increase life expectancy (23). The renowned benefit of polyamines in homeostatic system function such as nervous and immune ones in particular (14, 14, 24–26), and the decrease in their amounts when aging, seem to point towards the important role of polyamines for polyamines to improve aging and healthy longevity. HESPERIDIN: Flavonoids are bioactive substances found mainly in fruits and vegetables, with more than 15,000 molecules identified within this family (27). One of the best-known flavonoids is hesperidin, which is present in high concentrations in citrus fruits. When hesperidin reaches the intestine, the bacterial flora converts it into hesperetin, being the main metabolite of hesperidin (28). Hesperidin inhibits the secretion of pro-inflammatory cytokines such as TNFα, IL-6, IFN-γ and IL-2 (29–32). The intake of hesperidin has also been demonstrated to be highly safe (33), modulating leukocyte Gene expression, enhancing its antioxidant and inflammatory profile (34–36). NDL PRO HEALTH Biological Age does not contain any substances included in the WADA prohibited list in either their composition or during their manufacturing process

Warnings