TO RESOLVE: INSOMNIA STRESS ANXIETY PANIC ATTACKS   VALERIAN SLEEP SUPPORT - Valerian root may promote a sense of calm, and support a restful night’s sleep. General Description Amantilla is an extract produced from the root of Valeriana officinalis, commonly known as valerian.  The valerian herb in Amantilla has been used medicinally for at least 2,000 years. It has been included in many editions of the United States Dispensatory (Merck) since 1849, which reported the herb's effect on the nervous system. It is very effective in treating stress and anxiety. For some, Amantilla can also be used to induce sleep.  GABA (Gamma-aminobutyric acid), sometimes referred to as the body's natural tranquilizer is one of the amino acids produced in the brain. Valerian extracts like Amantilla stimulate GABA production in quantities sufficient to cause a sedative effect. Therefore, Amantilla may cause sedation by increasing the amount of GABA available in the synaptic clefts in the brain. Some Reported Medicinal Properties ANALGESIC ANODYNE ANTIANXIETY ANTIBACTERIAL ANTIHYPERTENSIVE ANTIHYSTERIC ANTI-INFLAMMATORY ANTISPASMODIC ANXIOLYTIC CARMINATIVE DIURETIC HYPNOTIC NERVINE SEDATIVE STOMACHIC Reasearch On Nutramedix Product IN VIVO – ACUTE ORAL TOXICITY TESTS An acute oral toxicity study was conducted by the University of Guayaquil, Ecuador concluding that Amantilla did not produce toxic effects, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary. Full Article Medical Conditions [peer-reviewed journals] ADHD Razlog, R., Pellow, J., & White, S. J. (2012). A pilot study on the efficacy of Valeriana officinalis mother tincture and Valeriana officinalis 3X in the treatment of attention deficit hyperactivity disorder. Health SA Gesondheid (Online), 17(1), 1-7. Full Article ANXIETY Baek, J. H., Nierenberg, A. A., & Kinrys, G. (2014). Clinical applications of herbal medicines for anxiety and insomnia; targeting patients with bipolar disorder. Australian & New Zealand Journal of Psychiatry, 48(8), 705-715. Full Article CANCER Hamaidia, M., Barez, P. Y., Carpentier, A., Lebecque, S., Miazek, K., Paul, A., ... & Frederich, M. (2016). From Valeriana officinalis to cancer therapy: the success of a bio-sourced compound. BASE.nano Full Article COGNITIVE FUNCTION Hassani, S., Alipour, A., Khezri, H. D., Firouzian, A., Zeydi, A. E., Baradari, A. G., ... & Zadeh, P. E. (2015). Can Valeriana officinalis root extract prevent early postoperative cognitive dysfunction after CABG surgery? A randomized, double-blind, placebo-controlled trial. Psychopharmacology, 232(5), 843-850. Full Article DEPRESSION Neamati, A., Chaman, F., Hosseini, M., & Boskabady, M. H. (2014). The effects of Valeriana officinalis L. hydro-alcoholic extract on depression like behavior in ovalbumin sensitized rats. Journal of pharmacy & bioallied sciences, 6(2), 97. Full Article Tang, J. Y., Zeng, Y. S., Chung, P., Wong, R., & Hagg, U. (2008). Effects of valeriana officinalis extract on rat depressive model. Journal of Chinese Clinical Medicine. Full Article Salami, M. R., Safarnejad, A., & Hamidi, H. (2007). Effect of salinity stress on morphological characters of Cuminum cyminum and Valeriana officinalis. Pajouhesh and Sazandegi. Abstract OROFACIAL DYSKINESIA Fachinetto, R., Villarinho, J. G., Wagner, C., Pereira, R. P., Ávila, D. S., Burger, M. E., ... & Ferreira, J. (2007). Valeriana officinalis does not alter the orofacial dyskinesia induced by haloperidol in rats: role of dopamine transporter. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 31(7), 1478-1486. Full Article OROFACIAL PAIN Nowacki, L. C., Worfel, P. R., Martins, P. F. A., Santos, R. S. D., Stechman-Neto, J., & Souza, W. M. D. (2015). Analgesic effect of Hypericum perforatum, Valeriana officinalis and Piper methysticum for orofacial pain.Brazilian Journal of Oral Sciences, 14(1), 60-65. Full Article PARKINSON DISEASE de Oliveria, D. M., Barreto, G., De Andrade, D. V. G., Saraceno, E., Aon-Bertolino, L., Capani, F., ... & Giraldez, L. D. (2009). Cytoprotective effect of Valeriana officinalis extract on an in vitro experimental model of Parkinson disease. Neurochemical Research, 34(2), 215-220. Full Article Medicinal Properties [peer-reviewed journals] ANTI-INFLAMMATORY Jacobo‐Herrera, N. J., Vartiainen, N., Bremner, P., Gibbons, S., Koistinaho, J., & Heinrich, M. (2006). F‐κB modulators from Valeriana officinalis. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 20(10), 917-919. Full Article ANTIOXIDANT Кatsarova, М., Dimitrova, S., Lukanov, L., Sadakov, F., Denev, P., Plotnikov, E., ... & Kostadinova, I. (2017). Antioxidant activity and nontoxicity of extracts from Valeriana officinalis, Мelissa officinalis, Crataegus monogyna, Hypericum perforatum, Serratula coronatа and combinations Antistress 1 and Antistress 2. Full Article Sudati, J. H., Vieira, F. A., Pavin, S. S., Dias, G. R. M., Seeger, R. L., Golombieski, R., ... & Barbosa, N. V. (2013). Valeriana officinalis attenuates the rotenone-induced toxicity in Drosophila melanogaster. Neurotoxicology, 37, 118-126. Full Article Sudati, J. H., Fachinetto, R., Pereira, R. P., Boligon, A. A., Athayde, M. L., Soares, F. A., ... & Rocha, J. B. T. (2009). In vitro antioxidant activity of Valeriana officinalis against different neurotoxic agents. Neurochemical Research, 34(8), 1372. Full Article ANXIOLYTIC Murphy, K., Kubin, Z. J., Shepherd, J. N., & Ettinger, R. (2010). Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats. Phytomedicine, 17(8-9), 674-678. Full Article Hattesohl, M., Feistel, B., Sievers, H., Lehnfeld, R., Hegger, M., & Winterhoff, H. (2008). Extracts of Valeriana officinalis L. s.l. show anxiolytic and antidepressant effects but neither sedative nor myorelaxant properties.Phytomedicine, 15(1-2), 2-15. Full Article ANTICONVULSANT Rezvani, M. E., Roohbakhsh, A., Allahtavakoli, M., & Shamsizadeh, A. (2010). Anticonvulsant effect of aqueous extract of Valeriana officinalis in amygdala-kindled rats: possible involvement of adenosine. Journal of Ethnopharmacology, 127(2), 313-318. Full Article Carrasco, M. C., Vallejo, J. R., Pardo‐de‐Santayana, M., Peral, D., Martín, M. Á., & Altimiras, J. (2009). Interactions of Valeriana officinalis L. and Passiflora incarnata L. in a patient treated with lorazepam.Phytotherapy Research, 23(12), 1795-1796. Full Article Hiller, K. O., & Zetler, G. (1996). Neuropharmacological studies on ethanol extracts of Valeriana officinalis L.: behavioural and anticonvulsant properties. Phytotherapy Research, 10(2), 145-151. Full Article ANTIMICROBIAL Letchamo, W., Ward, W., Heard, B., & Heard, D. (2004). Essential oil of Valeriana officinalis L. cultivars and their antimicrobial activity as influenced by harvesting time under commercial organic cultivation. Journal of Agricultural and Food Chemistry, 52(12), 3915-3919. Abstract GABA RECEPTOR MODULATOR Ortiz, J. G., Nieves-Natal, J., & Chavez, P. (1999). Effects of Valeriana officinalis extracts on [3 H] flunitrazepam binding, synaptosomal [3 H] GABA uptake, and hippocampal [3 H] GABA release. Neurochemical research, 24(11), 1373-1378. Full Article IMPROVED SLEEP QUALITY Barton, D. L., Atherton, P. J., Bauer, B. A., Moore Jr, D. F., Mattar, B. I., LaVasseur, B. I., ... & Morgenthaler, T. I. (2011). The use of valeriana officinalis (valerian) in improving sleep in patients who are undergoing treatment for cancer: a phase III randomized, placebo-controlled, double-blind study: NCCTG Trial, N01C5. The Journal of Supportive Oncology, 9(1), 24. Full Article Murti, K., Kaushik, M., Sangwan, Y., & Kaushik, A. (2011). Pharmacological properties of Valeriana officinalis—a review. Pharmacologyonline, 3, 641-646. Full Article Jacques Otobone, F., Colombo Martins, J. V., Trombelli, M. A., Andreatini, R., & Audi, E. A. (2005). Anxiolytic and sedative effects of a combined extract of Passiflora alata Dryander and Valeriana officinalis L. in rats. Acta Scientiarum. Health Sciences, 27(2). Full Article Fernández, S., Wasowski, C., Paladini, A. C., & Marder, M. (2004). Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis. Pharmacology Biochemistry and Behavior, 77(2), 399-404. Full Article Leathwood, P. D., Chauffard, F., Heck, E., & Munoz-Box, R. (1982). Aqueous extract of valerian root (Valeriana officinalis L.) improves sleep quality in man. Pharmacology Biochemistry and Behavior, 17(1), 65-71. Full Article RELAXANT Caudal, D., Guinobert, I., Lafoux, A., Bardot, V., Cotte, C., Ripoche, I., ... & Huchet, C. (2018). Skeletal muscle relaxant effect of a standardized extract of Valeriana officinalis L. after acute administration in mice. Journal of Traditional and Complementary Medicine, 8(2), 335-340. Full Article Pilerood, S. A., & Prakash, J. (2013). Nutritional and medicinal properties of valerian (Valeriana officinalis) herb: A review. International Journal of Food, Nutrition and Dietetics, 1(1), 25. Full Article Occhiuto, F., Pino, A., Palumbo, D. R., Samperi, S., De Pasquale, R., Sturlese, E., & Circosta, C. (2009). Relaxing effects of Valeriana officinalis extracts on isolated human non‐pregnant uterine muscle. Journal of Pharmacy and Pharmacology, 61(2), 251-256. Full Article Patient Reports "This product is incredible.  I was very stressed out and within 10 minutes after taking just 10 drops, I felt no stress at all.  It works great for my kids too.  It's great to know that I can give them something natural and safe that can calm them down in a few minutes." -I.M. “Amantilla works well. I use 15 drops in a little water just before going to sleep and it really makes a big difference.” – L.A “I take 10 drops of this straight under my tongue before bed and start feeling calmer and ready for sleep immediately. It's also great to take before eating so the body can process food on a less-stressed stomach, but I don't always remember to take advantage of that... I'm planning to keep two bottles-- one by my bed and one in my purse to fix that problem!” – L.C "I thought that I was sleeping well until I took Amantilla, but now I sleep great!  I took 30 drops at bedtime and I slept great.  I did not wake up once during the night and I woke up feeling very refreshed and didn't need coffee to get going.  Whenever I take it I can sleep about 2 hours less than I normally do."-T.I Dosage Information Insomnia: take 30 drops in 4 oz. of water at bedtime.   Severe Insomnia: take 30 drops every 30 minutes beginning 2 hours before bedtime for 5 nights.   Mild Anxiety: take 10 drops 2-4 times per day.   Moderate to Severe Anxiety, Panic Attacks: take 10-15 drops every 15 minutes in at least 2 oz. of water until symptoms are resolved. Can also put 2 droppers full (approximately 60 drops) in at least 480 ml (one pint) of water and sip over a 2-hour period, repeating until symptoms are resolved, then take 10 drops 2-4 times per day for maintenance. Safety Information An acute oral toxicity study was conducted by the University of Guayaquil, Ecuador concluding that Amantilla did not produce toxic effects, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary. Full Article PROPRIETARY WHOLE HERB EXTRACTION PROCESS - Highly bioavailable liquid for improved absorption. Nutramedix’s unique enhancement process optimizes the whole herb for a more powerful broad-spectrum extract. FROM NATURE - Our products are sourced from nature’s richest botanical resources, primarily Peru and the Amazon Rainforest. FEEL THE DIFFERENCE - Put 5-15 drops in 4 oz. of water and wait one minute before drinking. May be taken several times per day as needed, at bedtime or as directed by your physician. Do not use if pregnant or nursing. Shake well before each use. OVER 20 YEARS OF NUTRACEUTICAL INNOVATION - Founded in 1993, Nutramedix supplies highly bioavailable nutritional supplements to health care professionals and consumers. A majority of Nutramedix profits are donated to charitable organizations.